Here's the first state-of-the-art design reference on artificial implant surfaces. It takes you to the cutting-edge of efforts to understand and control the constant interactions taking place between biomaterials and biological media. The book explores processes and surface modifications that occur in various bio/non bio interfaces, and provides the latest performance-enhancing design, materials selection, and manufacturing guidance - including nanotechnology breakthroughs that are ushering in a new age of biomaterial design and applications. After an extensive discussion of biomedical surfaces attributes, the book addresses design issues that arise where materials and biofluids interface and the suppression or selective adsorption of biomacromolecules is a key objective. Implant lubrication and wear issues are covered, including adsorption of lubricants on surfaces and the tribology of the surfaces themselves. The book explores interaction issues crucial to predicting biomaterial interactions with body tissues, including protein adsorption and desorption processes, immune cell response, the assimilation and interaction of cells like osteocytes, and bacterial infection risks, and includes a chapter on biomedical surfaces manufacturing which emphasizes practical design issues. The volume also examines emerging nano-engineered materials including smartù surfaces that are responsive to host cells and tissues, as well as novel drug delivery surfaces developed with nano- and microtechnologies. Complete with techniques for measuring surface properties, this well-illustrated resource helps you design or select implants that deliver ever-higher levels of performance and durability.
IntroductionDefinition of Biomaterials. The Role of Surfaces in Governing Biomaterial Performance. Modifications to Surfaces in Contact with Biological Media (Biofluids, Tissues, Cells). The Adsorption of BiomacromoleculesPhysical-Chemical Fundamentals. ; HaemocompatibilityProcesses in Which Biomaterials Are in Contact with Biofluids. Stents. Heart Valves. Dialysis Machines. Design Issues Involving Suppression of Biomacromolecule Absorption or Selective Adsorption. ; LubricationMaterials Acting as Lubricants Between Solid Surfaces. Tribology of the Surfaces. Wear Issues. Particle Release from Prostheses. Mechanical Fatigue. ; Cells and TissuesBiocompatibility with Hard and Soft Tissues. Protein Adsorption and Desorption. Information Flow Between Surface and Cell. Immune Cell Response and Behavior. Assimilation Issues. Infection Risks. ; Drug Delivery SurfacesGeneral Properties of Nano- and Microporous Drug Delivery Materials. Percolation Theory. Interactions of Drug Delivery Particles and Biological Media. ; Prospects for Smart and Nano MaterialsSmart Surfaces. Interactions Between Cells/Tissues and Adaptive Nano Materials.;
-
Jeremy Ramsden
Jeremy Ramsden is a professor of nanotechnology in the Materials Department of Cranfield University, United Kingdom. He has published over 100 research articles covering topics in adsorption and desorption, biological macromolecules, and self-assembly and organizing processes at the nanoscale, and has chaired several international conferences devoted to biomolecular interactions. He is editor-in-chief of the Journal of Biological Physics and Chemistry, and founder of the MEMOCS research consortium uniting a dozen academic research groups and industrial firms in developing integrated-optical membrane-based sensors for medical and environmental applications. Dr. Ramsden studied Natural Sciences at Cambridge University and received his Ph.D. from the Institute of Chemical Physics, Swiss Federal Institute of Technology in Lausanne.