This single authoritative volume takes bio-device research and development to the next level, covering the latest advances in biomedical micro-electro-mechanical systems (MEMS) and nano-electro-mechanical systems (NEMS). This applications-focused book covers everything from fundamental mechanics of microactuators, to the most recent breakthroughs in the bio-manipulation and actuation of cells and genes. This trail-blazing work brings you up to speed on the synthesis and use of metallic nanoparticles in bio-sensing and drug delivery applications, including quantum dots-semiconductors nanocrystals-with their unique electronic and optical properties. It then explores the latest advances in micro and nano manipulation techniques, including manipulators and endoscopes for microsurgery, nano-based optical in-vitro and in-vivo imaging diagnostics, targeted delivery and guided therapy, optical trapping of subcellular components, and optical nano-surgery of subcellular components. Coverage also includes dielectrophoretic methods for biomedical applications, as well as hardware, software, and control issues involved with micro and nano precision robotic systems for cell manipulations and injections. A final section explores state-of-the-art dynamic modeling and analysis for gene manipulations. Showcasing the work of leading international experts and exhaustively referenced, this comprehensive and far-reaching volume helps you achieve greater success in the manipulation, control, modeling, and simulation of bio-devices at the micro and nano scale.
Introduction to Micro and Nano ManipulationsThe Third Industrial Revolution?. Micro - and Nano - Technologies. Applications and Trend. Nanotechnology Applications in Cancer Diagnosis and TherapyNanotechnology Approaches for In-vivo Diagnostics. Nanotechnology-based Drug Delivery Systems for Cancer Therapy. ; Nanoparticles for Biomedical ApplicationsSynthesis and Novel Properties of Metal Nanoparticles for Biomedical Applications. The Application of Metal Nanoparticles in Biomedicine. Biomedical Detection Using Novel Metal Nanoparticles. Drug Delivery and Bio-sensing With Magnetic Nanoparticles. Specific Properties of Quantum Dots. Quantum Dots as Fluorescent Biological Labels. Quantum Dots-Biomedical Applications. ; Micromanipulators in Minimally-Invasive ProceduresEndoscopic and In vivo Imaging Applications. Microtools. Sensors in Micromanipulators. Navigation. ; MicroactuatorsElectrostatic Actuators. Thermal Actuators. Piezoelectric Actuators. Shape Memory Alloy. Magnetic Actuators. ; Optical Nanomanipulations in a Living CellTwo Photon Fluorescence Microscopy. Second Harmonic Generation Microscopy. Laser Induced Micro-dissection. Optical Trapping. Optical Knock-out. ; Dielectrophoretic Methods for Biomedical ApplicationsDielectrophoretic Approaches to Bioparticle Manipulation and Characterization. Dielectrophoretic Approaches to Molecular Assays. ; Design, Analysis, Modeling, Simulation, and Control for Micro-nano Scale Cell ManipulationsApplications of Piezoactuated Micropositioning and Nanopositioning Systems. Construction of the Micro-Nano Robot as a Mechatronic System. Differential Kinematics of a Hybrid Robot for Cell Micro and Nano Manipulations. Hardware and Software for Development of Micro and Nanopositioning Systems. Intelligent Control of Piezoactuated Robot Using an Approximated Hysteresis Model in Micro- and Nanomanipulations. ; Dynamics Modeling and Analysis for Gene ManipulationsMajor Considerations for Gene Delivery. Electroporation. Hydroporation. Sonoporation. Microneedle and Microinjection. Optoinjection and Optoporation. Magnetofection. Dynamics Modeling of Gene Gun.;
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Ilie Talpasanu
Ilie Talpasanu is an assistant professor at the Wentworth Institute of Technology in Boston. He earned his Ph.D. in mechanical engineering at the University of Texas at Arlington, and Doctor Engineer in mechanics at the Polytechnic University Bucharest. He is a member in the executive committee of the American Society of Mechanical Engineers-West Texas Section.
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Tachung C. Yih
Tachung C. Yih is a professor of engineering and vice provost for research at Oakland University, Rochester, Michigan. He is a member of the American Academy of Nanomedicine and co-Editor-in-Chief of its official journal publication Nanomedicine: Nanotechnology, Biology and Medicine. He previously was professor and chair of the Mechanical Engineering and Biomechanics Department at the University of Texas at San Antonio. He received his Ph.D. in mechanical engineering from the Catholic University of America, Washington, D.C.