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Artech House UK
Plasmonic Optical Fiber Biosensors

Plasmonic Optical Fiber Biosensors

Copyright: 2023
Pages: 410
ISBN: 9781630819712

Print Book £116.00 Qty:
£110.00
Purchase Ebook
This unique resource will provide a practical and thorough vision on the most recent trends in plasmonic optical fiber biochemical sensing. This book gathers up-to-date technological information, and shows the maturity reached by the different subsequent technologies to experiment practical implementations. Plasmonic optical biosensors allow label-free and highly sensitive detection of analytes, usually within a dedicated microfluidic system that brings the sample to the biosensor surface. Compared to the bulky Kretschmann prism configuration implemented in most commercial systems, an optical fiber has been developed to improve measurements in a miniaturized system. Demonstrating roadmaps for the design process and practical implementation of plasmonic optical fiber biochemical sensors, this book helps the reader understanding the role of the fiber configuration and the functional coating in the fundamental properties of the derived optrodes. The book bridges the gap between theory and application of plasmonic optical fiber biosensors and highlights their main properties. Understanding these key physical properties is of paramount importance for the efficient design of sensing platforms that will meet the target specifications.

Chapter 1 (Introduction)

Rationale – Optical fibers Vs. Krestschmann prism
Positioning of the book content
Content review
Practical considerations

Chapter 2 (Physical concepts on surface plasmon sensing)

2.1. Mathematical formalism
2.1.1. Maxwell equations
2.1.2. Constitutive equations
2.1.3. Boundary conditions
2.1.4. Wave equations
2.1.5. Plasmons at a single interface
2.2. Excitation of surface plasmons
2.3. Long-range surface plasmons
2.4. Prism configurations & optical fiber counterpart
2.5. Localized surface plasmons
2.6. Plasmonic materials
2.7. Signal analysis and performance indicators
2.7.1. Signal analysis
2.7.2. Performance indicators
2.8. References

Chapter 3 (Multimode optical fiber plarforms)

3.1. Light propagation in optical fibers
3.1.1. Geometrical approach
3.1.2. Electromagnetism approach
3.2. Overview of multimode optical fibers
3.3. Unclad or etched configurations
3.4. Tapered configurations
3.5. D-shaped configurations
3.6. U-bent configurations
3.7. Interferometers – Hetero-core structures
3.8. Fiber end facets
3.9. References

Chapter 4 (Single-mode optical fiber platforms)

4.1. Overview of single-mode optical fibers
4.2. Etched, tapered and D-shaped configurations
4.3. Thinned uniform fiber Bragg grating configurations
4.3.1. Basics on uniform fiber Bragg gratings
4.3.2. Temperature sensitivity of uniform FBGs
4.3.3. Axial strain sensitivity of uniform FBGs
4.3.4. Pressure sensitivity of uniform FBGs
4.3.5. Transverse strain sensitivity of uniform FBGs
4.3.6. Refractometric sensitivity of uniform FBGs
4.4. Weakly and highly tilted fiber Bragg gratings
4.4.1. Weakly tilted fiber Bragg gratings
4.4.2. Excessively tilted fiber Bragg gratings
4.5. Eccentric fiber Bragg gratings
4.6. Long period fiber gratings
4.7. References

Chapter 5 (Specialty optical fiber platforms)

5.1. Polarization-maintaining optical fibers
5.1.1. Introduction to the concept of polarization-maintaining optical fibers
5.1.2. Use of polarization-maintaining optical fibers for plasmonic excitation
5.2. Microstructured optical fibers
5.3. Polymer optical fibers
5.4. Bioresorbable optical fibers
5.5. Fibers incorporated with metal nanoparticles
5.6. References

Chapter 6 (Immunosensors)

6.1. Introduction to biochemical sensors
6.2. Antibodies
6.3. Nanobodies
6.4. Affimers
6.5. Application of immunosensors
6.5.1. Immobilization strategies
6.5.2. Immunosensors
6.5.2.1. Protein detection
6.5.2.2. Virus and cell detection
6.5.2.3. Critical review
6.5.3. SPR Signal analysis
6.6. Conclusion
6.7. References

Chapter 7 (Nucleic acid-based receptors (DNA and RNA))

7.1. DNA receptors
7.1.1 Binding DNA receptors on glass
7.1.2. Binding DNA receptors on plastic
7.1.3. Binding DNA receptors on metals
7.1.4. Binding DNA receptors on polymeric materials
7.1.5. DNA spot arrays and microstructures
7.1.6. Design and synthesis of specific DNA 2D/3D structures
7.2. RNA/miRNA receptors
7.3. Aptamers
7.4. Applications of nucleic acid-based biosensors
7.4.1. Hybridization / complementary strand detection
7.4.2. Protein, toxin, and organic compound detection
7.4.3. Cell detection
7.4.4. Ion detection
7.5. Conclusion
7.6. References

Chapter 8 (Other bioreceptors for plasmonic biosensors)

8.1. Molecularly imprinted polymers (MIPs)
8.2. Enzymes
8.2.1. Enzymatic biosensors
8.2.2. Glucose biosensors
8.2.3. Snapshot on other enzymatic biosensors
8.2.4. The case of ELISA
8.2.5. Immobilization of enzymes on different substrates
8.2.6. Optical fiber-based enzymatic biosensors
8.3. Proteins
8.3.1. Anchor proteins (A, G, L)
8.3.2. Protein/antibodies or protein/protein interactions
8.4. Cells
8.5. Additional layers and matrices
8.5.1. Hydrogels
8.5.2. Dextran matrices
8.6. Optical fiber-based applications
8.7. References

Chapter 9 (Combined plasmonic sensors)

9.1. Electro-plasmonics
9.1.1. Voltammetry
9.1.2. Conductometry
9.1.3. Amperometry
9.1.4. Potentiometry
9.1.5. Combination with plasmonic optical fiber sensing
9.2. Magneto-plasmonics
9.3. Fluorescence-based and quantum dots-based plasmonics
9.4. Raman scattering
9.5. Ultrasound and radio-plasmonics
9.6. References

Chapter 10 (Current developments and future challenges)

10.1. Integrated optical fiber devices
10.1.1 Microfluidics
10.1.2. Optofluidics
10.1.3. Smartphone-based OF sensors
10.1.4. Multiplexing
10.2. Towards commercial practices
10.3. Point-of-care sensing and related innovation
10.4. Towards in situ sensing
10.5. Artificial intelligence (AI)-assisted sensing
10.6. From sensing to imaging
10.7. References

Chapter 11 (conclusion)

  • Christophe Caucheteur

    is a senior research Associate associate at the F.R.S.-FNRS and head of the Advanced Photonic Sensors Unit. In 2016, he cofounded the spin-off company B-SENS, developing smart sensing solutions based on the fiber Bragg grating technology. Caucheteur completed his master's in electrical engineering at the Faculty of Engineering (University of Mons, Belgium) in 2003. In 2007, he was awarded a PhD in Applied Sciences from the same institution.

  • Médéric Loyez

    is a young postdoctoral researcher who has studied and developed plasmonic optical fiber biosensors during his PhD thesis. He has a background in biochemistry. After learning new techniques in biological, chemical and photonics teams in Canada and the USA during a year of postdoctoral work, he is currently working as a research fellow of the F.R.S-FNRS in the laboratory of Prof. Ruddy Wattiez (Faculty of Science) and the Advanced Photonic Sensors Unit of Prof. Caucheteur.

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